Article
Cysteine 230 is essential for the structure and activity of the cytotoxic ligand TRAIL.
The Journal of biological chemistry - 7 Jul 2000
Bodmer J L, Meier P, Tschopp J, Schneider P
Abstract excerpt
Unlike other tumor necrosis factor family members, the cytotoxic ligand tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)/Apo-2L contains an unpaired cysteine residue (Cys(230)) in its receptor-binding domain. Here we show that the biological activity of both soluble recombinant TRAIL and cell-associated, full-length TRAIL is critically dependent on the presence of Cys(230). Mutation of Cys(230) to...
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