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Article

Trimeric coiled-coil domain of human pulmonary surfactant protein D enhances zinc-binding ability and biologic activity of soluble TRAIL.

Molecular immunology - 1 Jul 2009

Wu Xuechang, Li Ping, Qian Chaodong, Li Ou, Zhou Yinyan

Abstract excerpt

Unlike other TNF ligand family members, the homotrimeric tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) contains a buried zinc atom coordinated by three Cys230 residues from each subunit. The bound zinc ion is essential for maintaining the structure stability and bioactivity of TRAIL. To improve characteristics of TRAIL by modification to enhance its zinc-binding ability, we constructed a new...

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Share to Neoplasm Transplantation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Serum Albumin

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Share to Spectrometry, Mass, Electrospray Ionization

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Source

Identifiers

PMID: 19481806
DOI: 10.1016/j.molimm.2009.03.004

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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