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Article

Mechanism of zinc-mediated inhibition of caspase-9.

Protein science : a publication of the Protein Society - 1 Jul 2012

Huber Kristen L, Hardy Jeanne A

Abstract excerpt

Zinc-mediated inhibition is implicated in global caspase regulation, with relief of zinc-mediated inhibition central to both small-molecule and natively induced caspase activation. As an initiator, caspase-9 regulates the upstream stages of the apoptotic caspase cascade, making it a critical control point. Here we identify two distinct zinc-binding sites on caspase-9. The first site, composed of H237, C239, and...

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Identifiers

PMID: 22573662
DOI: 10.1002/pro.2090
PMCID: PMC3403442

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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