Article
The Val158Met polymorphism of the catechol-O-methyltransferase gene is not associated with the risk of sporadic or latent prostate cancer in Japanese men.
International journal of urology : official journal of the Japanese Urological Association - 1 Sept 2007
Suzuki Motofumi, Kurosaki Takayuki, Arai Tomio, Sawabe Motoji, Hosoi Takayuki, Kitamura Tadaichi
Abstract excerpt
AIM: Since catechol estrogens possess carcinogenetic potential, their detoxification may lead to reduced risk of carcinogenesis. Catechol-O-methyltransferase (COMT) catalyzes the O-methylation of catechol estrogens. The enzymatic activity of COMT has been shown to be governed by a functional single-nucleotide polymorphism represented by a G-to-A transition at codon 158, that results in a valine to methionine...
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