The Val158Met polymorphism of the catechol-O-methyltransferase gene is associated with the PSA-progression-free survival in prostate cancer patients treated with estramustine phosphate.

doi:10.1016/j.eururo.2005.07.007

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Article

The Val158Met polymorphism of the catechol-O-methyltransferase gene is associated with the PSA-progression-free survival in prostate cancer patients treated with estramustine phosphate.

European urology - 1 Nov 2005

Suzuki Motofumi, Mamun Mohammed Rafiqul Islam, Hara Kazuo, Ozeki Takeshi, Yamada Yasuhiko, Kadowaki Takashi, Honda Hidetoshi, Yanagihara Yoshitsugu, Ito Yoichi Minagawa, Kameyama Shuji, Ohta Nobutaka, Hosoi Takayuki, Arai Tomio, Sawabe Motoji, Takeuchi Takumi, Takahashi Satoru, Kitamura Tadaichi

Abstract excerpt

OBJECTIVE: The aim of our study is to find out the good responders for estramustine phosphate (EMP) therapy in patients with prostate cancer. We have focused on the metabolism of EMP and studied the association between a functional single-nucleotide polymorphism in the catechol-O-methyltransferase gene (Val158Met of COMT) and PSA-progression-free survival in Japanese patients with prostate cancer treated by EMP....

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PMID: 16126332
DOI: 10.1016/j.eururo.2005.07.007

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COMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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