Article
Lack of association between matrix metalloproteinase 8 promoter polymorphism and bronchiectasis in Koreans.
Journal of Korean medical science - 1 Aug 2007
Lee Jiwon, Kim Hye Ryoun, Min Joo Won, Park Jong Sun, Jin Sang Man, Han Sung Koo, Shim Young Soo, Yim Jae Joon
Abstract excerpt
The observation that human matrix metalloproteinase (MMP)-8 is over-expressed in ectatic bronchi in patients with bronchiectasis suggests that polymorphisms altering the expression of MMP-8 may contribute to the susceptibility to development of bronchiectasis. We evaluated the association between the presence of bronchiectasis in a Korean population and two single nucleotide polymorphisms (SNPs) (-799C/ T and...
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