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Article

Analysis of natural sequence variation and covariation in human immunodeficiency virus type 1 integrase.

Journal of virology - 1 Sept 2008

Myers Richard E, Pillay Deenan

Abstract excerpt

Human immunodeficiency virus type 1 (HIV-1) integrase inhibitors are in clinical trials, and raltegravir and elvitegravir are likely to be the first licensed drugs of this novel class of HIV antivirals. Understanding resistance to these inhibitors is important to maximize their efficacy. It has been shown that natural variation and covariation provide valuable insights into the development of resistance for...

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Identifiers

PMID: 18596095
DOI: 10.1128/JVI.01535-07
PMCID: PMC2546890

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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