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Article

Fibrinogen deficiency, but not plasminogen deficiency, increases mortality synergistically in combination with sickle hemoglobin SAD in transgenic mice.

American journal of hematology - 1 Dec 2007

Roszell Nancy J, Danton Mary Jo, Jiang Maorong, Witte David, Daugherty Cynthia, Grimes Timothy, Girdler Benjamin, Anderson Kathleen P, Franco Robert S, Degen Jay L, Joiner Clinton H

Abstract excerpt

Patients with sickle cell disease exhibit both acute and chronic activation of the coagulation and fibrinolytic systems. To test the relationship between sickle cell pathology and activation of the hemostatic system, mice with targeted deletions of plasminogen (Plg) or fibrinogen (Fib) were cross...

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Source

Identifiers

PMID: 17722076
DOI: 10.1002/ajh.20982

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-17722076-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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