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Article

Towards a transgenic mouse model of sickle cell disease: hemoglobin SAD.

The EMBO journal - 1 Nov 1991

Trudel M, Saadane N, Garel M C, Bardakdjian-Michau J, Blouquit Y, Guerquin-Kern J L, Rouyer-Fessard P, Vidaud D, Pachnis A, Roméo P H

Abstract excerpt

In order to obtain a transgenic mouse model of sickle cell disease, we have synthesized a novel human beta-globin gene, beta SAD, designed to increase the polymerization of the transgenic human hemoglobin S (Hb S) in vivo. beta SAD (beta S-Antilles-D Punjab) includes the beta 6Val substitution of the beta S chain, as well as two other mutations, Antilles (beta 23Ile) and D Punjab (beta 121Gln) each of which...

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Identifiers

PMID: 1915288
DOI: 10.1002/j.1460-2075.1991.tb04877.x
PMCID: PMC453038

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Source receipt: pubmed, retrieved 7 Sept 2026.

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