Article
Alcohol dehydrogenase 1B genotype and fetal alcohol syndrome: a HuGE minireview.
American journal of obstetrics and gynecology - 1 Jul 2007
Green Ridgely Fisk, Stoler Joan Marilyn
Abstract excerpt
Fetal alcohol syndrome (FAS), 1 of the most common developmental disabilities in the United States, occurs at a rate of 0.5-2.0:1000 live births. Animal model, family, and twin studies suggest a genetic component to FAS susceptibility. Alcohol dehydrogenases (ADHs) catalyze the rate-limiting step in alcohol metabolism. Studies of genetic associations with FAS have focused on the alcohol dehydrogenase 1B (ADH1B)...
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