Article

Biological foundation models illuminate annotation blind spots in evolutionarily divergent genomes

2026-05-16

Abstract excerpt

Chromosome-scale assemblies are increasingly available for non-model organisms, but functional annotation remains limited when deep evolutionary divergence erodes primary amino-acid sequence identity even though protein structural similarity can remain conserved. We present a hybrid annotation framework that decouples gene-model discovery from cross-species similarity assignment by combining Evo2-based ab initio...

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Literature Corpus work: 27faed5a-bd1b-5112-9de0-53d401f3a417
DOI: 10.64898/2026.05.15.724572

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