Article

Large-scale analyses of human microbiomes reveal thousands of small, novel genes and their predicted functions

2018-12-13

Abstract excerpt

Small proteins likely abound in prokaryotes, and may mediate much of the communication that occurs between organisms within a microbiome and their host. Unfortunately, small proteins are traditionally overlooked in biology, in part due to the computational and experimental difficulties in detecting them. To systematically identify novel small proteins, we carried out a large comparative genomics study on 1,773 HMP...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 130980bc-7b13-5eea-8b5c-293e217f5458
DOI: 10.1101/494179

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Large-scale analyses of human microbiomes reveal thousands of small, novel genes and their predicted functionsDOI 10.1101/494179Read

A unified sequence catalogue of over 280,000 genomes obtained from the human gut microbiomeSemantic proximity Read

A unified catalog of 204,938 reference genomes from the human gut microbiome.Semantic proximity Read

Lineage-specific microbial protein prediction enables large-scale exploration of protein ecology within the human gutSemantic proximity Read

sORFdb – A database for sORFs, small proteins, and small protein families in bacteriaSemantic proximity Read

SmProt: A Reliable Repository with Comprehensive Annotation of Small Proteins Identified from Ribosome ProfilingSemantic proximity Read

Metaproteomics as a tool for studying the protein landscape of human-gut bacterial speciesSemantic proximity Read

Expanding the human metaproteome: enhancing small open reading frame (smORF) prediction and ultra-deep detection of smORF-encoded proteins in the gut microbiomeSemantic proximity Read

Biophysical characterization of high-confidence, small human proteinsSemantic proximity Read

Functional prediction of proteins from the human gut archaeomeSemantic proximity Read

A comprehensive analysis of the global human gut archaeome from a thousand genome catalogueSemantic proximity Read

Comparative Metagenomics Revealed Commonly Enriched Gene Sets in Human Gut MicrobiomesSemantic proximity Read

Automated prediction and annotation of small proteins in microbial genomesSemantic proximity Read