Decidual cell FKBP51–progesterone receptor binding mediates maternal stress–induced preterm birth

Abstract excerpt

Significance Preterm birth (PTB) is the leading cause of neonatal morbidity and mortality. The genetics and molecular characteristics of PTB remain unclear. FKBP51 is an important mediator of the stress response and is implicated in the etiology of stress-related disorders. By combining studies in humans and Fkbp5 −/− mice, we show that maternal stress up-regulates FKBP51 levels and enhances binding of FKBP51 to...

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