Article
Physiological role for the cochaperone FKBP52 in androgen receptor signaling.
Molecular endocrinology (Baltimore, Md.) - 1 Jun 2005
Cheung-Flynn Joyce, Prapapanich Viravan, Cox Marc B, Riggs Daniel L, Suarez-Quian Carlos, Smith David F
Abstract excerpt
Molecular chaperones mediate multiple aspects of steroid receptor function, but the physiological importance of most receptor-associated cochaperones has not been determined. To help fill this gap, we targeted for disruption the mouse gene for the 52-kDa FK506 binding protein, FKBP52, a 90-kDa heat shock protein (Hsp90)-binding immunophilin found in steroid receptor complexes. A mouse line lacking FKBP52 (52KO)...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.