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Article

Differential effects of mutations in NS4B on West Nile virus replication and inhibition of interferon signaling.

Journal of virology - 1 Nov 2007

Evans Jared D, Seeger Christoph

Abstract excerpt

West Nile virus (WNV) is a human pathogen that can cause symptomatic infections associated with meningitis and encephalitis. Previously, we demonstrated that replication of WNV inhibits the interferon (IFN) signal transduction pathway by preventing the accumulation of phosphorylated Janus kinase 1 (JAK1) and tyrosine kinase 2 (Tyk2) (J. T. Guo et al., J. Virol. 79:1343-1350, 2005). Through a genetic analysis, we...

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Identifiers

PMID: 17715229
DOI: 10.1128/JVI.00791-07
PMCID: PMC2168815

Genes

JAK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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