Article
Association of SAPAP3 allelic variants with symptom dimensions and pharmacological treatment response in obsessive-compulsive disorder.
Experimental and clinical psychopharmacology - 1 Feb 2022
Naaz Safoora, Balachander Srinivas, Srinivasa Murthy Nithyananda, Ms Bhagyalakshmi, Sud Reeteka, Saha Priyanka, Narayanaswamy Janardhanan C, Reddy Yc Janardhan, Jain Sanjeev, Purushottam Meera, Viswanath Biju
Abstract excerpt
Though several SAPAP3 gene knockout studies in mice have implicated its role in compulsivity, human studies have failed to demonstrate its association with obsessive-compulsive disorder (OCD). We examined the association between allelic variants of a single nucleotide polymorphism in the SAPAP3 gene (rs6662980) with specific aspects of the OCD phenotype. A total of 200 individuals with OCD were genotyped using...
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