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Article

In vitro resistance profile of the hepatitis C virus NS3/4A protease inhibitor TMC435.

Antimicrobial agents and chemotherapy - 1 May 2010

Lenz Oliver, Verbinnen Thierry, Lin Tse-I, Vijgen Leen, Cummings Maxwell D, Lindberg Jimmy, Berke Jan Martin, Dehertogh Pascale, Fransen Els, Scholliers Annick, Vermeiren Katrien, Ivens Tania, Raboisson Pierre, Edlund Michael, Storm Susan, Vrang Lotta, de Kock Herman, Fanning Gregory C, Simmen Kenneth A

Abstract excerpt

TMC435 is a small-molecule inhibitor of the NS3/4A serine protease of hepatitis C virus (HCV) currently in phase 2 development. The in vitro resistance profile of TMC435 was characterized by selection experiments with HCV genotype 1 replicon cells and the genotype 2a JFH-1 system. In 80% (86/109)...

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Identifiers

PMID: 20176898
DOI: 10.1128/AAC.01452-09
PMCID: PMC2863659

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20176898-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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