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Article

Ceramide analogue 14S24 selectively recovers perturbed human skin barrier

18 Aug 2007

Abstract excerpt

BACKGROUND: Topical ceramide application is an effective therapeutic approach in skin disorders with disturbed barrier function, including atopic dermatitis and psoriasis. OBJECTIVES: To evaluate ceramide analogue N-tetracosanoyl-(l)-serine tetradecyl ester (14S24) using a novel ex vivo model. METHODS: Freshly excised human skin was disrupted by lipid extraction, tape stripping and sodium lauryl sulphate (SLS)...

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Identifiers

PMID: 17711529
DOI: 10.1111/j.1365-2133.2007.08113.x

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