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Article

Aberrant infection and persistence of varicella-zoster virus in human dorsal root ganglia <i>in vivo</i> in the absence of glycoprotein I

20 Aug 2007

Abstract excerpt

Varicella-zoster virus (VZV) causes varicella, establishes latency in sensory ganglia, and reactivates as herpes zoster. Human dorsal root ganglia (DRGs) xenografts in immunodeficient mice provide a model for evaluating VZV neuropathogenesis. Our investigation of the role of glycoprotein I (gI), which is dispensable in vitro, examines the functions of a VZV gene product during infection of human neural cells in...

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Identifiers

PMID: 17709745
DOI: 10.1073/pnas.0706023104

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