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Article

Varicella-zoster virus infection of human neural cells in vivo

9 Jul 2004

Abstract excerpt

Varicella-zoster virus (VZV) establishes latency in sensory ganglia and causes herpes zoster upon reactivation. These investigations in a nonobese diabetic severe combined immunodeficient mouse-human neural cell model showed that VZV infected both neurons and glial cells and spread efficiently from cell to cell in vivo. Neural cell morphology and protein synthesis were preserved, in contrast to destruction of...

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PMID: 15247414
DOI: 10.1073/pnas.0404016101

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