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Glycoprotein I of Varicella-Zoster Virus Is Required for Viral Replication in Skin and T Cells

28 Jul 2002

Abstract excerpt

Varicella-zoster virus (VZV) glycoprotein I (gI) is dispensable in cell culture; the SCIDhu model of VZV pathogenesis was used to determine whether gI is necessary in vivo. The parental and repaired viruses grew in human skin and thymus/liver implants, but the gI deletion mutant was not infectious. Thus, gI is essential for VZV infectivity in skin and T cells.

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PMID: 12134050
DOI: 10.1128/jvi.76.16.8468-8471.2002

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