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Functions of the unique N-terminal region of glycoprotein E in the pathogenesis of varicella-zoster virus infection

6 Dec 2009

Abstract excerpt

Varicella-zoster virus (VZV) is an alphaherpesvirus that infects skin, lymphocytes, and sensory ganglia. VZV glycoprotein E (gE) has a unique N-terminal region (aa1-188), which is required for replication and includes domains involved in secondary envelopment, efficient cell-cell spread, and skin infection in vivo. The nonconserved N-terminal region also mediates binding to the insulin-degrading enzyme (IDE),...

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PMID: 19966293
DOI: 10.1073/pnas.0912373107

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