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Extending Jak2V617F and MplW515 Mutation Analysis to Single Hematopoietic Colonies and B and T Lymphocytes

1 Jun 2007

Abstract excerpt

JAK2V617F and MPLW515L/K are myeloproliferative disorder (MPD)-associated mutations. We genotyped 552 individual hematopoietic colonies obtained by CD34+ cell culture from 16 affected patients (13 JAK2V617F and 3 MPLW515L/K) to determine (a) the proportion of colonies harboring a particular mutation in the presence or absence of cytokines, (b) the lineage distribution of endogenous colonies for each mutation, and...

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Identifiers

PMID: 17540852
DOI: 10.1634/stemcells.2007-0175

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Extending Jak2V617F and MplW515 Mutation Analysis to Single Hematopoietic Colonies and B and T LymphocytesPMID 17540852Read ↗

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