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Novel interferon-β-induced gene expression in peripheral blood cells

20 Aug 2007

Abstract excerpt

Type I IFNs are used for treating viral, neoplastic, and inflammatory disorders. The protein products encoded by IFN-stimulated genes (ISGs) likely mediate clinical effects of IFN in patients. Macroarray assays, used for studying ISG induction in IFN-treated patients, comprise genes identified predominantly through analysis of long-term cell lines. To discover genes induced selectively by IFN-beta in PBMC, we...

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PMID: 17709400
DOI: 10.1189/jlb.0507273

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