Article
T-cell ubiquitin ligand affects cell death through a functional interaction with apoptosis-inducing factor, a key factor of caspase-independent apoptosis.
The Journal of biological chemistry - 19 Oct 2007
Collingwood Therese S, Smirnova Evgeniya V, Bogush Marina, Carpino Nick, Annan Roland S, Tsygankov Alexander Y
Abstract excerpt
The lymphoid protein T-cell ubiquitin ligand (TULA)/suppressor of T-cell receptor signaling (Sts)-2 is associated with c-Cbl and ubiquitylated proteins and has been implicated in the regulation of signaling mediated by protein-tyrosine kinases. The results presented in this report indicate that TULA facilitates T-cell apoptosis independent of either T-cell receptor/CD3-mediated signaling or caspase activity. Mass...
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