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Article

The Cbl-interacting protein TULA inhibits dynamin-dependent endocytosis.

Experimental cell research - 1 May 2007

Bertelsen Vibeke, Breen Kamilla, Sandvig Kirsten, Stang Espen, Madshus Inger Helene

Abstract excerpt

The Cbl- and ubiquitin-interacting protein T-cell ubiquitin ligand (TULA) has been demonstrated to inhibit endocytosis and downregulation of ligand-activated EGF receptor (EGFR) by impairing Cbl-induced ubiquitination. We presently report that TULA additionally inhibited clathrin-dependent endocytosis in general, as both uptake of transferrin (Tf) and low-density lipoprotein (LDL) was inhibited. Additionally,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CD59 Antigens
Share to Clathrin
Share to Dynamins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lipoproteins, LDL

Share to Proto-Oncogene Proteins c-cbl

Share to src Homology Domains

Share to Transferrin

Source

Identifiers

PMID: 17382318
DOI: 10.1016/j.yexcr.2007.02.017

Genes

EGFR
EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The Cbl-interacting protein TULA inhibits dynamin-dependent endocytosis.PMID 17382318Read ↗

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