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Article

Regulation of Linear Ubiquitin Chain Assembly Complex by Caspase-Mediated Cleavage of RNF31.

Molecular and cellular biology - 15 Dec 2016

Joo Donghyun, Tang Yong, Blonska Marzenna, Jin Jianping, Zhao Xueqiang, Lin Xin

Abstract excerpt

Cell death and survival signaling pathways have opposed but fundamental functions for various cellular processes and maintain cell homeostasis through cross talk. Here we report a novel mechanism of interaction between these two pathways through the cleavage of RNF31 by caspases. RNF31, a component of the linear ubiquitin chain assembly complex (LUBAC), regulates cell survival by inducing linear ubiquitination of...

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Identifiers

PMID: 27669734
DOI: 10.1128/MCB.00474-16
PMCID: PMC5126289

Genes

RNF31
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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