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Article

tRNA import into yeast mitochondria is regulated by the ubiquitin-proteasome system.

FEBS letters - 4 Sept 2007

Brandina Irina, Smirnov Alexandre, Kolesnikova Olga, Entelis Nina, Krasheninnikov Igor A, Martin Robert P, Tarassov Ivan

Abstract excerpt

In Saccharomyces cerevisiae, one of two cytosolic lysine-tRNAs is partially imported into mitochondria. We demonstrate that three components of the ubiquitin/26S proteasome system (UPS), Rpn13p, Rpn8p and Doa1p interact with the imported tRNA and with the essential factor of its mitochondrial targeting, pre-Msk1p. Genetic and biochemical assays demonstrate that UPS plays a dual regulatory role, since the overall...

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Identifiers

PMID: 17707817
DOI: 10.1016/j.febslet.2007.08.013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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