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Article

A Los1p-independent pathway for nuclear export of intronless tRNAs in Saccharomycescerevisiae.

Proceedings of the National Academy of Sciences of the United States of America - 16 Apr 2002

Feng Wenqin, Hopper Anita K

Abstract excerpt

Los1p, the Saccharomyces cerevisiae exportin-t homologue, binds tRNA and functions in pre-tRNA splicing and export of mature tRNA from the nucleus to the cytosol. Because LOS1 is unessential in yeast, other pathways for tRNA nuclear export must exist. We report that Cca1p, which adds nucleotides C, C, and A to the 3' end of tRNAs, is a multicopy suppressor of the defect in tRNA nuclear export caused by los1 null...

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Identifiers

PMID: 11959996
DOI: 10.1073/pnas.082682699
PMCID: PMC122783

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