Article
The N-terminal region of eukaryotic translation initiation factor 5A signals to nuclear localization of the protein.
Biochemical and biophysical research communications - 19 Oct 2007
Parreiras-E-Silva Lucas T, Gomes Marcelo D, Oliveira Eduardo B, Costa-Neto Claudio M
Abstract excerpt
The eukaryotic translation initiation factor 5A (eIF5A) is a ubiquitous protein of eukaryotic and archaeal organisms which undergoes hypusination, a unique post-translational modification. We have generated a polyclonal antibody against murine eIF5A, which in immunocytochemical assays in B16-F10 cells revealed that the endogenous protein is preferentially localized to the nuclear region. We therefore analyzed...
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