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Article

The EGFR mutation status affects the relative biological effectiveness of carbon-ion beams in non-small cell lung carcinoma cells.

Scientific reports - 11 Jun 2015

Amornwichet Napapat, Oike Takahiro, Shibata Atsushi, Nirodi Chaitanya S, Ogiwara Hideaki, Makino Haruhiko, Kimura Yuka, Hirota Yuka, Isono Mayu, Yoshida Yukari, Ohno Tatsuya, Kohno Takashi, Nakano Takashi

Abstract excerpt

Carbon-ion radiotherapy (CIRT) holds promise to treat inoperable locally-advanced non-small cell lung carcinoma (NSCLC), a disease poorly controlled by standard chemoradiotherapy using X-rays. Since CIRT is an extremely limited medical resource, selection of NSCLC patients likely to benefit from it is important; however, biological predictors of response to CIRT are ill-defined. The present study investigated the...

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Share to Carcinoma, Non-Small-Cell Lung
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Breaks, Double-Stranded

Share to DNA Repair

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Share to Gene Expression Regulation, Neoplastic

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Source

Open in PubMed Open full text

Identifiers

PMID: 26065573
DOI: 10.1038/srep11305
PMCID: PMC4463964

Genes

EGFR
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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