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Induction of reproductive cell death in Caenorhabditis elegans across entire linear-energy-transfer range of carbon-ion irradiation.

DNA repair - 1 Mar 2018

Chen Liangwen, Tang Huangqi, Du Yan, Dai Zhangyu, Wang Ting, Wu Lijun, Zhou Libin, Bian Po

Abstract excerpt

Heavy-ion radiation has attracted extensive attention as an effective cancer therapy because of the varying energy deposition along its track and its high cell-killing effect. Reproductive cell death (RCD), also known as clonogenic death, is an important mode of death of the cancer cells after radiotherapy. Although RCD induced by heavy-ion irradiation with various linear energy transfers has been demonstrated...

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PMID: 29414052
DOI: 10.1016/j.dnarep.2018.01.009

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