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Article

A seizure-prone phenotype is associated with altered free-running rhythm in Pten mutant mice.

Brain research - 7 Sept 2007

Ogawa Shiori, Kwon Chang-Hyuk, Zhou Jing, Koovakkattu Della, Parada Luis F, Sinton Christopher M

Abstract excerpt

Conditional deletion of Pten (phosphatase and tensin homolog on chromosome ten) in differentiated cortical and hippocampal neurons in the mouse results in seizures, macrocephaly, social interaction deficits and anxiety, reminiscent of human autism spectrum disorder. Here we extended our previous examination of these mice using electroencephalogram/electromyogram (EEG/EMG) monitoring and found age-related...

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Identifiers

PMID: 17706614
DOI: 10.1016/j.brainres.2007.06.074

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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