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Article

A search for modifying genetic factors in CHEK2:c.1100delC breast cancer patients.

Scientific reports - 20 Jul 2021

Wendt Camilla, Muranen Taru A, Mielikäinen Lotta, Thutkawkorapin Jessada, Blomqvist Carl, Jiao Xiang, Ehrencrona Hans, Tham Emma, Arver Brita, Melin Beatrice, Kuchinskaya Ekaterina, Stenmark Askmalm Marie, Paulsson-Karlsson Ylva, Einbeigi Zakaria, von Wachenfeldt Väppling Anna, Kalso Eija, Tasmuth Tiina, Kallioniemi Anne, Aittomäki Kristiina, Nevanlinna Heli, Borg Åke, Lindblom Annika

Abstract excerpt

The risk of breast cancer associated with CHEK2:c.1100delC is 2-threefold but higher in carriers with a family history of breast cancer than without, suggesting that other genetic loci in combination with CHEK2:c.1100delC confer an increased risk in a polygenic model. Part of the excess familial risk has been associated with common low-penetrance variants. This study aimed to identify genetic loci that modify...

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Identifiers

PMID: 34285278
DOI: 10.1038/s41598-021-93926-x
PMCID: PMC8292481

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A search for modifying genetic factors in CHEK2:c.1100delC breast cancer patients.PMID 34285278Read ↗

Genetic modifiers of CHEK2*1100delC-associated breast cancer risk.Semantic proximity Read ↗

CHEK2 1100delC variant and breast cancer risk in Caucasians: a meta-analysis based on 25 studies with 29,154 cases and 37,064 controls.Semantic proximity Read ↗

CHEK2*1100delC genotyping for clinical assessment of breast cancer risk: meta-analyses of 26,000 patient cases and 27,000 controls.Semantic proximity Read ↗

CHEK2*1100delC and susceptibility to breast cancer: a collaborative analysis involving 10,860 breast cancer cases and 9,065 controls from 10 studies.Semantic proximity Read ↗

Age- and Tumor Subtype-Specific Breast Cancer Risk Estimates for CHEK2*1100delC Carriers.Semantic proximity Read ↗

Increased risk of breast cancer associated with CHEK2*1100delC.Semantic proximity Read ↗

Cohort profile: a nationwide study in Dutch CHEK2 c.1100delC families using the infrastructure of the HEreditary Breast and Ovarian cancer study Netherlands - Hebon-CHEK2.Semantic proximity Read ↗

CHEK2 1100delC is a susceptibility allele for HNPCC-related colorectal cancer.Semantic proximity Read ↗

Increased Risk for Other Cancers in Addition to Breast Cancer for CHEK2*1100delC Heterozygotes Estimated From the Copenhagen General Population Study.Semantic proximity Read ↗

Frequency of CHEK2*1100delC in New York breast cancer cases and controls.Semantic proximity Read ↗

The CHEK2*1100delC variant acts as a breast cancer risk modifier in non-BRCA1/BRCA2 multiple-case families.Semantic proximity Read ↗

Interaction between CHEK2*1100delC and other low-penetrance breast-cancer susceptibility genes: a familial studySemantic proximity Read ↗

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