Article
Tumour characteristics and prognosis of breast cancer patients carrying the germline CHEK2*1100delC variant.
Journal of medical genetics - 1 Oct 2004
de Bock G H, Schutte M, Krol-Warmerdam E M M, Seynaeve C, Blom J, Brekelmans C T M, Meijers-Heijboer H, van Asperen C J, Cornelisse C J, Devilee P, Tollenaar R A E M, Klijn J G M
Abstract excerpt
BACKGROUND: The germline CHEK2*1100delC variant has been associated with breast cancer in multiple case families where involvement of BRCA1 and BRCA2 has been excluded. METHODS: We have investigated the tumour characteristics and prognosis of carriers of this germline variant by means of a prospective cohort study in an unselected cohort of 1084 consecutive patients with primary breast cancer. Data were collected...
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