Article
Frequency of CHEK2*1100delC in New York breast cancer cases and controls.
BMC medical genetics - 15 Jan 2003
Offit Kenneth, Pierce Heather, Kirchhoff Tomas, Kolachana Prema, Rapaport Beth, Gregersen Peter, Johnson Steven, Yossepowitch Orit, Huang Helen, Satagopan Jaya, Robson Mark, Scheuer Lauren, Nafa Khedoudja, Ellis Nathan
Abstract excerpt
BACKGROUND: The 1100delC CHEK2 allele has been associated with a 1.4-4.7 fold increased risk for breast cancer in women carrying this mutation. While the frequency of 1100delC was 1.1-1.4% in healthy Finnish controls, the frequency of this allele in a North American control population and in North American breast cancer kindreds remains unclear. METHODS: We genotyped 1665 healthy New York volunteers and 300 cases...
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