Article
A role for Haemophilus ducreyi Cu,ZnSOD in resistance to heme toxicity.
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine - 1 Jun 2008
Negari Shahin, Sulpher Jeff, Pacello Francesca, Ingrey Keely, Battistoni Andrea, Lee B Craig
Abstract excerpt
The Cu,Zn superoxide dismutase (Cu,ZnSOD) from Haemophilus ducreyi is the only enzyme of this class which binds a heme molecule at its dimer interface. To explore the role of the enzyme in this heme-obligate bacterium, a sodC mutant was created by insertional inactivation. No difference in growth rate was observed during heme limitation. In contrast, under heme rich conditions growth of the sodC mutant was...
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