Article
Copper- and zinc-containing superoxide dismutase (Cu/ZnSOD) is required for the protection of Candida albicans against oxidative stresses and the expression of its full virulence.
Microbiology (Reading, England) - 1 Nov 2002
Hwang Cheol-Sang, Rhie Gi-Eun, Oh Jang-Hyun, Huh Won-Ki, Yim Hyung-Soon, Kang Sa-Ouk
Abstract excerpt
Copper- and zinc-containing superoxide dismutase (Cu/ZnSOD) is suspected to be one of the anti-oxidant enzymes and virulence determinants active in some pathogenic micro-organisms. To elucidate the role of Cu/ZnSOD in the major human fungal pathogen Candida albicans, its gene, designated SOD1, was disrupted by the URA-blaster technique. The resulting sod1/sod1 mutant showed delayed hyphal growth on Spider medium...
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