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Defective DNA base excision repair in brain from individuals with Alzheimer's disease and amnestic mild cognitive impairment

17 Aug 2007

Abstract excerpt

Oxidative stress is thought to play a role in the pathogenesis of Alzheimer's disease (AD) and increased oxidative DNA damage has been observed in brain tissue from AD patients. Base excision repair (BER) is the primary DNA repair pathway for small base modifications such as alkylation, deamination and oxidation. In this study, we have investigated alterations in the BER capacity in brains of AD patients. We...

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PMID: 17704129
DOI: 10.1093/nar/gkm605

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