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DNA Oxidation in Alzheimer's Disease

1 Nov 2006

Abstract excerpt

Oxidative damage to DNA may play an important role in aging and neurodegenerative diseases such as Alzheimer's disease (AD). Attack on DNA by reactive oxygen species, particularly hydroxyl radicals, can lead to strand breaks, DNA-DNA and DNA-protein cross-linking, sister chromatid exchange and translocation, and formation of at least 20 oxidized base adducts. Modification of DNA bases can lead to mutation and...

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PMID: 17034348
DOI: 10.1089/ars.2006.8.2039

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