Article
Myoferlin regulates vascular endothelial growth factor receptor-2 stability and function.
The Journal of biological chemistry - 19 Oct 2007
Bernatchez Pascal N, Acevedo Lisette, Fernandez-Hernando Carlos, Murata Takahisa, Chalouni Cecile, Kim Jiae, Erdjument-Bromage Hediye, Shah Vijay, Gratton Jean-Philippe, McNally Elizabeth M, Tempst Paul, Sessa William C
Abstract excerpt
Myoferlin and dysferlin are members of the ferlin family of membrane proteins. Recent studies have shown that mutation or genetic disruption of myoferlin or dysferlin promotes muscular dystrophy-related phenotypes in mice, which are the result of impaired plasma membrane integrity. However, no biological functions have been ascribed to myoferlin in non-muscle tissues. Herein, using a proteomic analysis of...
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