Article
Dysferlin interacts with annexins A1 and A2 and mediates sarcolemmal wound-healing.
The Journal of biological chemistry - 12 Dec 2003
Lennon Niall J, Kho Alvin, Bacskai Brian J, Perlmutter Sarah L, Hyman Bradley T, Brown Robert H
Abstract excerpt
Mutations in the dysferlin gene cause limb girdle muscular dystrophy type 2B and Miyoshi myopathy. We report here the results of expression profile analyses and in vitro investigations that point to an interaction between dysferlin and the Ca2+ and lipid-binding proteins, annexins A1 and A2, and define a role for dysferlin in Ca2+-dependent repair of sarcolemmal injury through a process of vesicle fusion....
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