Article

Kindlin-2-Moesin interaction orchestrates sprouting angiogenesis via modulating endothelial membrane mechanics and VEGF signaling

2026-02-26

Abstract excerpt

Membrane mechanics play a crucial role in cellular signaling and fate determination, yet their impact on angiogenesis remains poorly understood. Here, we identify Kindlin-2 as a key regulator of sprouting angiogenesis via regulating endothelial membrane tension through its interaction with Moesin, a crucial linker protein between the cell membrane and the actin cortex. Mechanistically, Kindlin-2 binds to the N62 r...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 371cf908-668f-53cf-9548-6774b4fddf95
DOI: 10.64898/2026.02.24.707842

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Kindlin-2-Moesin interaction orchestrates sprouting angiogenesis via modulating endothelial membrane mechanics and VEGF signalingDOI 10.64898/2026.02.24.707842Read

Tmem2 Regulates Embryonic Vegf Signaling by Controlling Hyaluronic Acid Turnover.Semantic proximity Read

Myoferlin regulates vascular endothelial growth factor receptor-2 stability and function.Semantic proximity Read

Constitutive Active Mutant TIE2 Induces Enlarged Vascular Lumen Formation with Loss of Apico-basal Polarity and Pericyte RecruitmentSemantic proximity Read

Phenotypic Transition of Vascular Smooth Muscle Cells Induced by Endothelial TIE2 Mutations in Venous MalformationsSemantic proximity Read

Novel interactions of perlecan: Unraveling perlecan's role in angiogenesisSemantic proximity Read

Loss-of-Function Mutations in ELMO2 Cause Intraosseous Vascular Malformation by Impeding RAC1 Signaling.Semantic proximity Read

Endothelial ANGPT2 insufficiency impairs retinal vascularization with ROP-like neovascular tuftsSemantic proximity Read

Genetic mosaics reveal mechanisms of resistance to VEGF signaling loss during angiogenesisSemantic proximity Read

Phenotypic heterogeneity of the endothelium: I. Structure, function, and mechanisms.Semantic proximity Read

Pan-cancer analyses suggest kindlin-associated global mechanochemical alterationsSemantic proximity Read

NRP2 as an Emerging Angiogenic Player; Promoting Endothelial Cell Adhesion and Migration by Regulating Recycling of α5 IntegrinSemantic proximity Read

TMEM30A deficiency in endothelial cells impairs cell proliferation and angiogenesisSemantic proximity Read