Article
Characterization of the peptide-binding specificity of the chimpanzee class I alleles A 0301 and A 0401 using a combinatorial peptide library.
Immunogenetics - 1 Sept 2007
Sidney John, Peters Bjoern, Moore Carrie, Pencille Timothy J, Ngo Sandy, Masterman Kelly-Anne, Asabe Shinichi, Pinilla Clemencia, Chisari Francis V, Sette Alesandro
Abstract excerpt
Chimpanzees represent important models for studying several human pathogens. In the present study, we utilized a combinatorial peptide library to characterize the binding specificities of the chimpanzee class I molecules Patr A 0301 and A 0401, both of which are present in about 17% of chimpanzees. Patr A 0301 was found to recognize peptides using the canonical position 2/C-terminus spacing, with the small...
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