Article
Molecular and immunological significance of chimpanzee major histocompatibility complex haplotypes for hepatitis C virus immune response and vaccination studies.
Journal of virology - 1 Jun 2002
Mizukoshi Eishiro, Nascimbeni Michelina, Blaustein Joshua B, Mihalik Kathleen, Rice Charles M, Liang T Jake, Feinstone Stephen M, Rehermann Barbara
Abstract excerpt
The chimpanzee is a critical animal model for studying cellular immune responses to infectious pathogens such as hepatitis B and C viruses, human immunodeficiency virus, and malaria. Several candidate vaccines and immunotherapies for these infections aim at the induction or enhancement of cellular immune responses against viral epitopes presented by common human major histocompatibility complex (MHC) alleles. To...
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