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Article

The LxCxE pRb interaction domain of cyclin D1 is dispensable for murine development.

Cancer research - 15 Aug 2007

Landis Mark W, Brown Nelson E, Baker Gregory L, Shifrin Anna, Das Manjusri, Geng Yan, Sicinski Piotr, Hinds Philip W

Abstract excerpt

Cyclin D1 is a multifunctional, tumor-associated protein that interacts with pRb via a conserved LxCxE motif, activates a kinase partner, directs the phosphorylation of pRb, activates cyclin E-cyclin-dependent kinase 2 (cdk2) by titrating Cip/Kip cdk inhibitors, and modulates the activity of a variety of transcription factors. It is thought that some of the proproliferative function of cyclin D1 is exerted by...

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Amino Acid Motifs
Cell Cycle Proteins
Cerebellum
Cyclin D1
G1 Phase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mammary Glands, Animal

Retinoblastoma Protein

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PMID: 17699765
DOI: 10.1158/0008-5472.CAN-07-1207

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