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Article

Rescue of cyclin D1 deficiency by knockin cyclin E.

Cell - 11 Jun 1999

Geng Y, Whoriskey W, Park M Y, Bronson R T, Medema R H, Li T, Weinberg R A, Sicinski P

Abstract excerpt

D-type cyclins and cyclin E represent two very distinct classes of mammalian G1 cyclins. We have generated a mouse strain in which the coding sequences of the cyclin D1 gene (Ccnd1) have been deleted and replaced by those of human cyclin E (CCNE). In the tissues and cells of these mice, the expression pattern of human cyclin E faithfully reproduces that normally associated with mouse cyclin D1. The replacement of...

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Identifiers

PMID: 10380928
DOI: 10.1016/s0092-8674(00)80788-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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