Article
Cyclin D3/CDK11p58 Complex Is Involved in the Repression of Androgen Receptor
14 Aug 2007
Abstract excerpt
Androgen receptor (AR) is essential for the maintenance of the male reproductive systems and is critical for the carcinogenesis of human prostate cancers (PCas). D-type cyclins are closely related to the repression of AR function. It has been well documented that cyclin D1 inhibits AR function through multiple mechanisms, but the mechanism of how cyclin D3 exerts its repressive role in the AR signaling pathway...
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