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Article

Cyclin E as a Coactivator of the Androgen Receptor

21 Aug 2000

Abstract excerpt

Androgens play an important role in the growth of prostate cancer, but the molecular mechanism that underlies development of resistance to antiandrogen therapy remains unknown. Cyclin E has now been shown to increase the transactivation activity of the human androgen receptor (AR) in the presence of its ligand dihydrotestosterone. The enhancement of AR activity by cyclin E was resistant to inhibition by the...

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PMID: 10953010
DOI: 10.1083/jcb.150.4.873

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Cyclin E as a Coactivator of the Androgen ReceptorPMID 10953010Read ↗

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