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Article

A dominant-negative mutant of androgen receptor coregulator ARA54 inhibits androgen receptor-mediated prostate cancer growth.

The Journal of biological chemistry - 15 Feb 2002

Miyamoto Hiroshi, Rahman Mujib, Takatera Hiroshi, Kang Hong-Yo, Yeh Shuyuan, Chang Hong-Chiang, Nishimura Kazuo, Fujimoto Naohiro, Chang Chawnshang

Abstract excerpt

The ligand-bound androgen receptor (AR) regulates target genes via a mechanism involving coregulators such as androgen receptor-associated 54 (ARA54). We investigated whether the interruption of the AR coregulator function could lead to down-regulation of AR activity. Using in vitro mutagenesis and a yeast two-hybrid screening assay, we have isolated a mutant ARA54 (mt-ARA54) carrying a point mutation at amino...

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PMID: 11673464
DOI: 10.1074/jbc.M108312200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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